Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins

Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp41)(3)] typically exist in a metastable closed conformation (state 1). Binding the CD4 receptor triggers Env to undergo extensive conformational changes to mediate virus entry. We identified specific gp120 res...

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Publicado en:mBio
Autores principales: Herschhorn, Alon, Ma, Xiaochu, Gu, Christopher, Ventura, John D., Castillo-Menendez, Luis, Melillo, Bruno, Terry, Daniel S., Smith, Amos B., Blanchard, Scott C., Munro, James B., Mothes, Walther, Finzi, Andrés, Sodroski, Joseph
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080382/
https://ncbi.nlm.nih.gov/pubmed/27795397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01598-16
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