Chargement en cours...

A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry

Binding to the primary receptor, CD4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer (gp120(3)/gp41(3)) of human immunodeficiency virus (HIV-1) that are important for virus entry into host cells. These changes include an “opening” of the trimer, creation of a bi...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Chem Biol
Auteurs principaux: Herschhorn, Alon, Gu, Christopher, Espy, Nicole, Richard, Jonathan, Finzi, Andrés, Sodroski, Joseph G.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231716/
https://ncbi.nlm.nih.gov/pubmed/25174000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1623
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!