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A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry
Binding to the primary receptor, CD4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer (gp120(3)/gp41(3)) of human immunodeficiency virus (HIV-1) that are important for virus entry into host cells. These changes include an “opening” of the trimer, creation of a bi...
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| Udgivet i: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4231716/ https://ncbi.nlm.nih.gov/pubmed/25174000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1623 |
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