α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-Oxygen Bond

α-Hemoglobin (αHb)-stabilizing protein (AHSP) is a molecular chaperone that assists hemoglobin assembly. AHSP induces changes in αHb heme coordination, but how these changes are facilitated by interactions at the αHb·AHSP interface is not well understood. To address this question we have used NMR, x...

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Autori principali: Dickson, Claire F., Rich, Anne M., D'Avigdor, William M. H., Collins, Daniel A. T., Lowry, Jason A., Mollan, Todd L., Khandros, Eugene, Olson, John S., Weiss, Mitchell J., Mackay, Joel P., Lay, Peter A., Gell, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707698/
https://ncbi.nlm.nih.gov/pubmed/23696640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437509
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