α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-Oxygen Bond

α-Hemoglobin (αHb)-stabilizing protein (AHSP) is a molecular chaperone that assists hemoglobin assembly. AHSP induces changes in αHb heme coordination, but how these changes are facilitated by interactions at the αHb·AHSP interface is not well understood. To address this question we have used NMR, x...

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Detalhes bibliográficos
Main Authors: Dickson, Claire F., Rich, Anne M., D'Avigdor, William M. H., Collins, Daniel A. T., Lowry, Jason A., Mollan, Todd L., Khandros, Eugene, Olson, John S., Weiss, Mitchell J., Mackay, Joel P., Lay, Peter A., Gell, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707698/
https://ncbi.nlm.nih.gov/pubmed/23696640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437509
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