α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-Oxygen Bond

α-Hemoglobin (αHb)-stabilizing protein (AHSP) is a molecular chaperone that assists hemoglobin assembly. AHSP induces changes in αHb heme coordination, but how these changes are facilitated by interactions at the αHb·AHSP interface is not well understood. To address this question we have used NMR, x...

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Autors principals: Dickson, Claire F., Rich, Anne M., D'Avigdor, William M. H., Collins, Daniel A. T., Lowry, Jason A., Mollan, Todd L., Khandros, Eugene, Olson, John S., Weiss, Mitchell J., Mackay, Joel P., Lay, Peter A., Gell, David A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707698/
https://ncbi.nlm.nih.gov/pubmed/23696640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.437509
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