Kinetics of α-Globin Binding to α-Hemoglobin Stabilizing Protein (AHSP) Indicate Preferential Stabilization of Hemichrome Folding Intermediate

Human α-hemoglobin stabilizing protein (AHSP) is a conserved mammalian erythroid protein that facilitates the production of Hemoglobin A by stabilizing free α-globin. AHSP rapidly binds to ferrous α with association (k′(AHSP)) and dissociation (k(AHSP)) rate constants of ≈10 μm(−1) s(−1) and 0.2 s(−...

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Bibliographic Details
Main Authors: Mollan, Todd L., Khandros, Eugene, Weiss, Mitchell J., Olson, John S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322864/
https://ncbi.nlm.nih.gov/pubmed/22298770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313247
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