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Kinetics of α-Globin Binding to α-Hemoglobin Stabilizing Protein (AHSP) Indicate Preferential Stabilization of Hemichrome Folding Intermediate
Human α-hemoglobin stabilizing protein (AHSP) is a conserved mammalian erythroid protein that facilitates the production of Hemoglobin A by stabilizing free α-globin. AHSP rapidly binds to ferrous α with association (k′(AHSP)) and dissociation (k(AHSP)) rate constants of ≈10 μm(−1) s(−1) and 0.2 s(−...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322864/ https://ncbi.nlm.nih.gov/pubmed/22298770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313247 |
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