Role of α-Globin H Helix in the Building of Tetrameric Human Hemoglobin: Interaction with α-Hemoglobin Stabilizing Protein (AHSP) and Heme Molecule

Alpha-Hemoglobin Stabilizing Protein (AHSP) binds to α-hemoglobin (α-Hb) or α-globin and maintains it in a soluble state until its association with the β-Hb chain partner to form Hb tetramers. AHSP specifically recognizes the G and H helices of α-Hb. To investigate the degree of interaction of the v...

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Bibliographic Details
Published in:PLoS One
Main Authors: Domingues-Hamdi, Elisa, Vasseur, Corinne, Fournier, Jean-Baptiste, Marden, Michael C., Wajcman, Henri, Baudin-Creuza, Véronique
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219717/
https://ncbi.nlm.nih.gov/pubmed/25369055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111395
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