Small Molecule Agonist of Very Late Antigen-4 (VLA-4) Integrin Induces Progenitor Cell Adhesion

Activation of the integrin family of cell adhesion receptors on progenitor cells may be a viable approach to enhance the effects of stem cell-based therapies by improving cell retention and engraftment. Here, we describe the synthesis and characterization of the first small molecule agonist identifi...

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Autori principali: Vanderslice, Peter, Biediger, Ronald J., Woodside, Darren G., Brown, Wells S., Khounlo, Sayadeth, Warier, Navin D., Gundlach, C. William, Caivano, Amy R., Bornmann, William G., Maxwell, David S., McIntyre, Bradley W., Willerson, James T., Dixon, Richard A. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707645/
https://ncbi.nlm.nih.gov/pubmed/23703610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479634
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