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Discovery of Very Late Antigen-4 (VLA-4, α(4)β(1) Integrin) Allosteric Antagonists
Integrins are cell adhesion receptors that mediate cell-to-cell, or cell-to-extracellular matrix adhesion. They represent an attractive target for treatment of multiple diseases. Two classes of small molecule integrin inhibitors have been developed. Competitive antagonists bind directly to the integ...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037658/ https://ncbi.nlm.nih.gov/pubmed/21131351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162636 |
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