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Discovery of Very Late Antigen-4 (VLA-4, α(4)β(1) Integrin) Allosteric Antagonists

Integrins are cell adhesion receptors that mediate cell-to-cell, or cell-to-extracellular matrix adhesion. They represent an attractive target for treatment of multiple diseases. Two classes of small molecule integrin inhibitors have been developed. Competitive antagonists bind directly to the integ...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Chigaev, Alexandre, Wu, Yang, Williams, D. Bart, Smagley, Yelena, Sklar, Larry A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037658/
https://ncbi.nlm.nih.gov/pubmed/21131351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162636
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