The innate immune DNA sensor cGAS produces a non-canonical cyclic-di-nucleotide that activates human STING

The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic-GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS). cGAMP activates an interferon response by bindi...

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Autori principali: Diner, Elie J., Burdette, Dara L., Wilson, Stephen C., Monroe, Kathryn M., Kellenberger, Colleen A., Hyodo, Mamoru, Hayakawa, Yoshihiro, Hammond, Ming C., Vance, Russell E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706192/
https://ncbi.nlm.nih.gov/pubmed/23707065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.009
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