The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides

Type I interferons (IFNs) are central regulators of the innate and adaptive immune responses to viral and bacterial infections. Type I IFNs are induced upon cytosolic detection of microbial nucleic acids, including DNA, RNA, and the bacterial second messenger cyclic-di-GMP (c-di-GMP). In addition, a...

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Main Authors: Sauer, John-Demian, Sotelo-Troha, Katia, von Moltke, Jakob, Monroe, Kathryn M., Rae, Chris S., Brubaker, Sky W., Hyodo, Mamoru, Hayakawa, Yoshihiro, Woodward, Joshua J., Portnoy, Daniel A., Vance, Russell E.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2011
Teme:
Host Response and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028833/
https://ncbi.nlm.nih.gov/pubmed/21098106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00999-10
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