STING inhibitors target the cyclic dinucleotide binding pocket

Cytosolic DNA activates cGAS (cytosolic DNA sensor cyclic AMP-GMP synthase)-STING (stimulator of interferon genes) signaling, which triggers interferon and inflammatory responses that help defend against microbial infection and cancer. However, aberrant cytosolic self-DNA in Aicardi–Goutière’s syndr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hong, Ze, Mei, Jiahao, Li, Chenhui, Bai, Guohui, Maimaiti, Munire, Hu, Haiyang, Yu, Wenying, Sun, Li, Zhang, Lele, Cheng, Dan, Liao, Yixian, Li, Senlin, You, Yanping, Sun, Hongbin, Huang, Jing, Liu, Xing, Lieberman, Judy, Wang, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214703/
https://ncbi.nlm.nih.gov/pubmed/34099558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2105465118
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