STING inhibitors target the cyclic dinucleotide binding pocket

Cytosolic DNA activates cGAS (cytosolic DNA sensor cyclic AMP-GMP synthase)-STING (stimulator of interferon genes) signaling, which triggers interferon and inflammatory responses that help defend against microbial infection and cancer. However, aberrant cytosolic self-DNA in Aicardi–Goutière’s syndr...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Hong, Ze, Mei, Jiahao, Li, Chenhui, Bai, Guohui, Maimaiti, Munire, Hu, Haiyang, Yu, Wenying, Sun, Li, Zhang, Lele, Cheng, Dan, Liao, Yixian, Li, Senlin, You, Yanping, Sun, Hongbin, Huang, Jing, Liu, Xing, Lieberman, Judy, Wang, Chen
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2021
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214703/
https://ncbi.nlm.nih.gov/pubmed/34099558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2105465118
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы