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The innate immune DNA sensor cGAS produces a non-canonical cyclic-di-nucleotide that activates human STING
The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic-GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS). cGAMP activates an interferon response by bindi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3706192/ https://ncbi.nlm.nih.gov/pubmed/23707065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.009 |
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