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Dystroglycan Function Requires Xylosyl- and Glucuronyltransferase Activities of LARGE

Posttranslational modification of alpha-dystroglycan (α-DG) by the like-acetylglucosaminyltransferase (LARGE) is required for it to function as an extracellular matrix (ECM) receptor. Mutations in the LARGE gene have been identified in congenital muscular dystrophy patients with brain abnormalities....

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Main Authors: Inamori, Kei-ichiro, Yoshida-Moriguchi, Takako, Hara, Yuji, Anderson, Mary E., Yu, Liping, Campbell, Kevin P.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702376/
https://ncbi.nlm.nih.gov/pubmed/22223806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1214115
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