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Dystroglycan Function Requires Xylosyl- and Glucuronyltransferase Activities of LARGE
Posttranslational modification of alpha-dystroglycan (α-DG) by the like-acetylglucosaminyltransferase (LARGE) is required for it to function as an extracellular matrix (ECM) receptor. Mutations in the LARGE gene have been identified in congenital muscular dystrophy patients with brain abnormalities....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3702376/ https://ncbi.nlm.nih.gov/pubmed/22223806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1214115 |
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