The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation

Dystroglycan is a cell membrane receptor that organizes the basement membrane by binding ligands in the extracellular matrix. Proper glycosylation of the α-dystroglycan (α-DG) subunit is essential for these activities, and lack thereof results in neuromuscular disease. Currently, neither the glycan...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Willer, Tobias, Inamori, Kei-ichiro, Venzke, David, Harvey, Corinne, Morgensen, Greg, Hara, Yuji, Beltrán Valero de Bernabé, Daniel, Yu, Liping, Wright, Kevin M, Campbell, Kevin P
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2014
Onderwerpen:
Biochemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227050/
https://ncbi.nlm.nih.gov/pubmed/25279699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03941
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