Endogenous Glucuronyltransferase Activity of LARGE or LARGE2 Required for Functional Modification of α-Dystroglycan in Cells and Tissues

Mutations in the LARGE gene have been identified in congenital muscular dystrophy (CMD) patients with brain abnormalities. Both LARGE and its paralog, LARGE2 (also referred to as GYLTL1B) are bifunctional glycosyltransferases with xylosyltransferase (Xyl-T) and glucuronyltransferase (GlcA-T) activit...

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Opis bibliograficzny
Główni autorzy: Inamori, Kei-ichiro, Willer, Tobias, Hara, Yuji, Venzke, David, Anderson, Mary E., Clarke, Nigel F., Guicheney, Pascale, Bönnemann, Carsten G., Moore, Steven A., Campbell, Kevin P.
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2014
Hasła przedmiotowe:
Glycobiology and Extracellular Matrices
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192470/
https://ncbi.nlm.nih.gov/pubmed/25138275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597831
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