Endogenous Glucuronyltransferase Activity of LARGE or LARGE2 Required for Functional Modification of α-Dystroglycan in Cells and Tissues

Mutations in the LARGE gene have been identified in congenital muscular dystrophy (CMD) patients with brain abnormalities. Both LARGE and its paralog, LARGE2 (also referred to as GYLTL1B) are bifunctional glycosyltransferases with xylosyltransferase (Xyl-T) and glucuronyltransferase (GlcA-T) activit...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Inamori, Kei-ichiro, Willer, Tobias, Hara, Yuji, Venzke, David, Anderson, Mary E., Clarke, Nigel F., Guicheney, Pascale, Bönnemann, Carsten G., Moore, Steven A., Campbell, Kevin P.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2014
Θέματα:
Glycobiology and Extracellular Matrices
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192470/
https://ncbi.nlm.nih.gov/pubmed/25138275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597831
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