Structural basis of laminin binding to the LARGE glycans on dystroglycan

Dystroglycan is a highly glycosylated extracellular matrix receptor with essential functions in skeletal muscle and the nervous system. Reduced matrix binding by α-dystroglycan (α-DG) due to perturbed glycosylation is a pathological feature of several forms of muscular dystrophy. Like-acetylglucosam...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Briggs, David C., Yoshida-Moriguchi, Takako, Zheng, Tianqing, Venzke, David, Anderson, Mary, Strazzulli, Andrea, Moracci, Marco, Yu, Liping, Hohenester, Erhard, Campbell, Kevin P.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030134/
https://ncbi.nlm.nih.gov/pubmed/27526028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2146
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