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Structural basis of laminin binding to the LARGE glycans on dystroglycan
Dystroglycan is a highly glycosylated extracellular matrix receptor with essential functions in skeletal muscle and the nervous system. Reduced matrix binding by α-dystroglycan (α-DG) due to perturbed glycosylation is a pathological feature of several forms of muscular dystrophy. Like-acetylglucosam...
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| Udgivet i: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030134/ https://ncbi.nlm.nih.gov/pubmed/27526028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2146 |
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