Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity

Active-site serine D,D-transpeptidases belonging to the penicillin-binding protein family (PBPs) have been considered for a long time as essential for peptidoglycan cross-linking in all bacteria. However, bypass of the PBPs by an L,D-transpeptidase (Ldt(fm)) conveys high-level resistance to β-lactam...

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Hauptverfasser: Triboulet, Sébastien, Dubée, Vincent, Lecoq, Lauriane, Bougault, Catherine, Mainardi, Jean-Luc, Rice, Louis B., Ethève-Quelquejeu, Mélanie, Gutmann, Laurent, Marie, Arul, Dubost, Lionel, Hugonnet, Jean-Emmanuel, Simorre, Jean-Pierre, Arthur, Michel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701632/
https://ncbi.nlm.nih.gov/pubmed/23861815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067831
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