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Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome and the pluripotency network are re-established during PGC development. Here we demonstrate that Prdm14 contribut...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
European Molecular Biology Organization
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701237/ https://ncbi.nlm.nih.gov/pubmed/23670199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.67 |
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