Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome and the pluripotency network are re-established during PGC development. Here we demonstrate that Prdm14 contribut...

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Detalhes bibliográficos
Main Authors: Grabole, Nils, Tischler, Julia, Hackett, Jamie A, Kim, Shinseog, Tang, Fuchou, Leitch, Harry G, Magnúsdóttir, Erna, Surani, M Azim
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701237/
https://ncbi.nlm.nih.gov/pubmed/23670199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.67
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