Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

Early mammalian development entails transit through naive pluripotency towards post-implantation epiblast, which subsequently gives rise to primordial germ cells (PGC), the founding germline population. To investigate these cell fate transitions, we developed a compound-reporter to track cellular id...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Hackett, Jamie A., Huang, Yun, Günesdogan, Ufuk, Gretarsson, Kristjan A., Kobayashi, Toshihiro, Surani, M. Azim
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191455/
https://ncbi.nlm.nih.gov/pubmed/30327475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06230-0
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