TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency

Transition from primed to naive pluripotency is associated with dynamic changes in transposable element (TE) expression and demethylation of imprinting control regions (ICRs). In mouse, ICR methylation and TE expression are each regulated by TRIM28; however, the role of TRIM28 in humans is less clea...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Tao, Yu, Yen, Ming-Ren, Chitiashvili, Tsotne, Nakano, Haruko, Kim, Rachel, Hosohama, Linzi, Tan, Yao Chang, Nakano, Atsushi, Chen, Pao-Yang, Clark, Amander T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768987/
https://ncbi.nlm.nih.gov/pubmed/29290627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.11.020
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