Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome and the pluripotency network are re-established during PGC development. Here we demonstrate that Prdm14 contribut...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Grabole, Nils, Tischler, Julia, Hackett, Jamie A, Kim, Shinseog, Tang, Fuchou, Leitch, Harry G, Magnúsdóttir, Erna, Surani, M Azim
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: European Molecular Biology Organization 2013
Konular:
Scientific Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701237/
https://ncbi.nlm.nih.gov/pubmed/23670199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.67
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller