Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

MCL-1 is an essential BCL-2 family member that promotes the survival of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we report that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy manifested by a loss of cardiac contract...

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Détails bibliographiques
Auteurs principaux: Wang, Xi, Bathina, Madhavi, Lynch, John, Koss, Brian, Calabrese, Christopher, Frase, Sharon, Schuetz, John D., Rehg, Jerold E., Opferman, Joseph T.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2013
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701191/
https://ncbi.nlm.nih.gov/pubmed/23788622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.215855.113
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