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Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
MCL-1 is an essential BCL-2 family member that promotes the survival of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we report that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy manifested by a loss of cardiac contract...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701191/ https://ncbi.nlm.nih.gov/pubmed/23788622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.215855.113 |
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