Anti-Apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Couples Mitochondrial Fusion to Respiration

MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of multiple cell lineages, is also among the most highly amplified genes in cancer. Although MCL-1 is known to oppose cell death, precisely how it functions to promote survival of normal and malignant cells is poorly und...

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Detalhes bibliográficos
Main Authors: Perciavalle, Rhonda M., Stewart, Daniel P., Koss, Brian, Lynch, John, Milasta, Sandra, Bathina, Madhavi, Temirov, Jamshid, Cleland, Megan M., Pelletier, Stéphane, Schuetz, John D., Youle, Richard J., Green, Douglas R., Opferman, Joseph T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401947/
https://ncbi.nlm.nih.gov/pubmed/22544066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2488
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