Sensitization of ovarian carcinoma cells to Bcl-x(L)-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family

BACKGROUND: Our work has been carried out in the context of the therapeutic failure in ovarian carcinoma, which remains the leading cause of death by gynecologic malignancy. In these tumours, recurrence and subsequent acquired chemoresistance constitute major hurdles to successful therapy. Here we s...

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Bibliographische Detailangaben
Hauptverfasser: Tomasina, Julie, Malzert-Freon, Aurélie, Giffard, Florence, Brotin, Emilie, Louis, Marie-Hélène, Abeilard, Edwige, Rault, Sylvain, Gauduchon, Pascal, Poulain, Laurent
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Brief Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700836/
https://ncbi.nlm.nih.gov/pubmed/23735052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-6-38
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