Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-Bclx(L) strategies through Mcl-1 down-regulation

The anti-apoptotic proteins Bcl-x(L) and Mcl-1 have been identified to play a pivotal role in apoptosis resistance in ovarian cancer and constitute key targets for innovative therapeutic strategies. Although BH3-mimetics (i.e. ABT-737) potently inhibit Bcl-x(L) activity, targeting Mcl-1 remains a hu...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bonnefond, Marie-Laure, Florent, Romane, Lenoir, Sophie, Lambert, Bernard, Abeilard, Edwige, Giffard, Florence, Louis, Marie-Hélène, Elie, Nicolas, Briand, Mélanie, Vivien, Denis, Poulain, Laurent, Gauduchon, Pascal, N'Diaye, Monique
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188062/
https://ncbi.nlm.nih.gov/pubmed/30338034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26084
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