Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib

Ovarian cancer represents the first cause of mortality from gynecologic malignancies due to frequent chemoresistance occurrence. Increasing the [BH3-only Bim, Puma, Noxa proapoptotic]/[Bcl-x(L), Mcl-1 antiapoptotic] proteins ratio was proven to efficiently kill ovarian carcinoma cells and developmen...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Florent, Romane, Weiswald, Louis-Bastien, Lambert, Bernard, Brotin, Emilie, Abeilard, Edwige, Louis, Marie-Hélène, Babin, Guillaume, Poulain, Laurent, N’Diaye, Monique
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235085/
https://ncbi.nlm.nih.gov/pubmed/32424251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2588-8
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