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Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib
Ovarian cancer represents the first cause of mortality from gynecologic malignancies due to frequent chemoresistance occurrence. Increasing the [BH3-only Bim, Puma, Noxa proapoptotic]/[Bcl-x(L), Mcl-1 antiapoptotic] proteins ratio was proven to efficiently kill ovarian carcinoma cells and developmen...
में बचाया:
| में प्रकाशित: | Cell Death Dis |
|---|---|
| मुख्य लेखकों: | , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group UK
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7235085/ https://ncbi.nlm.nih.gov/pubmed/32424251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2588-8 |
| टैग : |
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