Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents in Human Melanoma Cells

Human melanoma cells are very resistant to treatment with chemotherapeutic agents, and melanoma shows poor response to chemotherapeutic therapy. We describe a strong synergistic proapoptotic effect of the Bcl-2 family inhibitor ABT-737 and the standard antimelanoma drugs, namely, dacarbazine and fot...

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Main Authors: Weber, Arnim, Kirejczyk, Zofia, Potthoff, Stephanie, Ploner, Christian, Häcker, Georg
格式: Artigo
語言:Inglês
出版: Neoplasia Press Inc. 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670574/
https://ncbi.nlm.nih.gov/pubmed/19412422
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