γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells

INTRODUCTION: Inappropriate Notch signaling, downstream of γ-secretase activity, is understood to have tumor-promoting function and to be associated with poor outcome in cancer, of the breast in particular. The molecular basis of antitumoral effects of its inhibitors, however, remains poorly charact...

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Detaylı Bibliyografya
Asıl Yazarlar: Séveno, Céline, Loussouarn, Delphine, Bréchet, Sophie, Campone, Mario, Juin, Philippe, Barillé-Nion, Sophie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446359/
https://ncbi.nlm.nih.gov/pubmed/22703841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3214
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