Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1

BACKGROUND: Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of anti-apoptotic proteins of the Bcl-2 family that has shown promise in various preclinical tumour models. RESULTS: We here report a strong over-additive pro-apoptotic effect of ABT-737 and...

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Detaylı Bibliyografya
Asıl Yazarlar: Zall, Henry, Weber, Arnim, Besch, Robert, Zantl, Niko, Häcker, Georg
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2010
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901261/
https://ncbi.nlm.nih.gov/pubmed/20576107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-164
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