Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer

The sensitivity to ABT-737, a prototype BH3 mimetic drug, varies in a broad range in small cell lung cancer (SCLC) cells. We have previously shown that the expression of Noxa, a BH3-only pro-apoptotic BCL-2 family protein, is the critical determinant of ABT-737 sensitivity. We show here that Noxa re...

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Bibliografiset tiedot
Päätekijät: Nakajima, W, Hicks, M A, Tanaka, N, Krystal, G W, Harada, H
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2014
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944277/
https://ncbi.nlm.nih.gov/pubmed/24525728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.6
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