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Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer
The sensitivity to ABT-737, a prototype BH3 mimetic drug, varies in a broad range in small cell lung cancer (SCLC) cells. We have previously shown that the expression of Noxa, a BH3-only pro-apoptotic BCL-2 family protein, is the critical determinant of ABT-737 sensitivity. We show here that Noxa re...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944277/ https://ncbi.nlm.nih.gov/pubmed/24525728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.6 |
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