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The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin

Tumour progression and therapy resistance in squamous cell carcinoma of the skin (SCC) is strongly associated with resistance to intrinsic mitochondrial apoptosis. We thus investigated the role of various anti-apoptotic Bcl-2 proteins for apoptosis protection in SCC using the BH3 agonist ABT737 that...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Geserick, P, Wang, J, Feoktistova, M, Leverkus, M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540197/
https://ncbi.nlm.nih.gov/pubmed/25210795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.379
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