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The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin
Tumour progression and therapy resistance in squamous cell carcinoma of the skin (SCC) is strongly associated with resistance to intrinsic mitochondrial apoptosis. We thus investigated the role of various anti-apoptotic Bcl-2 proteins for apoptosis protection in SCC using the BH3 agonist ABT737 that...
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| Опубликовано в: : | Cell Death Dis |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4540197/ https://ncbi.nlm.nih.gov/pubmed/25210795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.379 |
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