The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin

Tumour progression and therapy resistance in squamous cell carcinoma of the skin (SCC) is strongly associated with resistance to intrinsic mitochondrial apoptosis. We thus investigated the role of various anti-apoptotic Bcl-2 proteins for apoptosis protection in SCC using the BH3 agonist ABT737 that...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Geserick, P, Wang, J, Feoktistova, M, Leverkus, M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540197/
https://ncbi.nlm.nih.gov/pubmed/25210795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.379
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