Sensitization of ovarian carcinoma cells to Bcl-x(L)-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family

BACKGROUND: Our work has been carried out in the context of the therapeutic failure in ovarian carcinoma, which remains the leading cause of death by gynecologic malignancy. In these tumours, recurrence and subsequent acquired chemoresistance constitute major hurdles to successful therapy. Here we s...

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Główni autorzy: Tomasina, Julie, Malzert-Freon, Aurélie, Giffard, Florence, Brotin, Emilie, Louis, Marie-Hélène, Abeilard, Edwige, Rault, Sylvain, Gauduchon, Pascal, Poulain, Laurent
Format: Artigo
Język:Inglês
Wydane: BioMed Central 2013
Hasła przedmiotowe:
Brief Communication
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700836/
https://ncbi.nlm.nih.gov/pubmed/23735052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-6-38
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