miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-X(L) and EGFR leading to BIM activation

We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibit...

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Опубликовано в: :Cell Death Dis
Главные авторы: Denoyelle, C, Lambert, B, Meryet-Figuière, M, Vigneron, N, Brotin, E, Lecerf, C, Abeilard, E, Giffard, F, Louis, M-H, Gauduchon, P, Juin, P, Poulain, L
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649504/
https://ncbi.nlm.nih.gov/pubmed/25299770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.389
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