Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-x(L) inhibitors on human ovarian carcinoma cells

The inhibition of two major anti-apoptotic proteins, Bcl-x(L) and Mcl-1, appears essential to destroy chemoresistant cancer cells. We have studied their concomitant inhibition, using ABT 737 or siRNA targeting XL1 and citrate, a molecule which reduces the expression level of Mcl-1. Two cisplatin-che...

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Bibliographic Details
Main Authors: Lincet, Hubert, Kafara, Perrine, Giffard, Florence, Abeilard-Lemoisson, Edwige, Duval, Maryline, Louis, Marie-Hélène, Poulain, Laurent, Icard, Philippe
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851866/
https://ncbi.nlm.nih.gov/pubmed/24103422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-6-72
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