Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-x(L) inhibitors on human ovarian carcinoma cells

The inhibition of two major anti-apoptotic proteins, Bcl-x(L) and Mcl-1, appears essential to destroy chemoresistant cancer cells. We have studied their concomitant inhibition, using ABT 737 or siRNA targeting XL1 and citrate, a molecule which reduces the expression level of Mcl-1. Two cisplatin-che...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lincet, Hubert, Kafara, Perrine, Giffard, Florence, Abeilard-Lemoisson, Edwige, Duval, Maryline, Louis, Marie-Hélène, Poulain, Laurent, Icard, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851866/
https://ncbi.nlm.nih.gov/pubmed/24103422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-6-72
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados