Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-Bclx(L) strategies through Mcl-1 down-regulation

The anti-apoptotic proteins Bcl-x(L) and Mcl-1 have been identified to play a pivotal role in apoptosis resistance in ovarian cancer and constitute key targets for innovative therapeutic strategies. Although BH3-mimetics (i.e. ABT-737) potently inhibit Bcl-x(L) activity, targeting Mcl-1 remains a hu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Bonnefond, Marie-Laure, Florent, Romane, Lenoir, Sophie, Lambert, Bernard, Abeilard, Edwige, Giffard, Florence, Louis, Marie-Hélène, Elie, Nicolas, Briand, Mélanie, Vivien, Denis, Poulain, Laurent, Gauduchon, Pascal, N'Diaye, Monique
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188062/
https://ncbi.nlm.nih.gov/pubmed/30338034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26084
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge