Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis

PURPOSE: To determine the role of the CCL2/CCR2 axis and inflammatory monocytes (IM; CCR2(+)/CD14(+)) as immunotherapeutic targets in the treatment of pancreatic cancer (PC). EXPERIMENTAL DESIGN: Survival analysis was performed to determine if the prevalence of pre-operative blood monocytes correlat...

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Main Authors: Sanford, Dominic E., Belt, Brian A., Panni, Roheena Z., Mayer, Allese, Deshpande, Anjali D., Carpenter, Danielle, Mitchem, Jonathan B., Plambeck-Suess, Stacey M., Worley, Lori A., Goetz, Brian D., Wang-Gillam, Andrea, Eberlein, Timothy J., Denardo, David G., Goedegebuure, S. Peter, Linehan, David C.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700620/
https://ncbi.nlm.nih.gov/pubmed/23653148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0525
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