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Prime-Boost Interval Matters: A Randomized Phase 1 Study to Identify the Minimum Interval Necessary to Observe the H5 DNA Influenza Vaccine Priming Effect

Background. H5 DNA priming was previously shown to improve the antibody response to influenza A(H5N1) monovalent inactivated vaccine (MIV) among individuals for whom there was a 24-week interval between prime and boost receipt. This study defines the shortest prime-boost interval associated with an...

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Main Authors: Ledgerwood, Julie E., Zephir, Kathryn, Hu, Zonghui, Wei, Chih-Jen, Chang, LeeJah, Enama, Mary E., Hendel, Cynthia S., Sitar, Sandra, Bailer, Robert T., Koup, Richard A., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699006/
https://ncbi.nlm.nih.gov/pubmed/23633407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit180
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