Phase I clinical evaluation of seasonal influenza hemagglutinin (HA) DNA vaccine prime followed by trivalent influenza inactivated vaccine (IIV3) boost

Annual influenza vaccination reduces the risks of influenza when the vaccines are well matched to circulating strains, but development of an approach that induces broader and more durable immune responses would be beneficial. We conducted two companion Phase 1 studies, VRC 307 and VRC 309, over sequ...

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Detalhes bibliográficos
Publicado no:Contemp Clin Trials
Main Authors: Ledgerwood, Julie E., Hu, Zonghui, Costner, Pamela, Yamshchikov, Galina, Enama, Mary E., Plummer, Sarah, Hendel, Cynthia S., Holman, Lasonji, Larkin, Brenda, Gordon, Ingelise, Bailer, Robert T., Poretz, Donald M., Sarwar, Uzma, Kabadi, Alisha, Koup, Richard, Mascola, John R., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751067/
https://ncbi.nlm.nih.gov/pubmed/26275339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2015.08.006
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