Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial

BACKGROUND: Ebolavirus and Marburgvirus cause severe hemorrhagic fever with high mortality and are potential bioterrorism agents. There are no available vaccines or therapeutic agents. Previous clinical trials evaluated transmembrane-deleted and point-mutation Ebolavirus glycoproteins (GPs) in candi...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Sarwar, Uzma N., Costner, Pamela, Enama, Mary E., Berkowitz, Nina, Hu, Zonghui, Hendel, Cynthia S., Sitar, Sandra, Plummer, Sarah, Mulangu, Sabue, Bailer, Robert T., Koup, Richard A., Mascola, John R., Nabel, Gary J., Sullivan, Nancy J., Graham, Barney S., Ledgerwood, Julie E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318920/
https://ncbi.nlm.nih.gov/pubmed/25225676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu511
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