Prime-Boost Interval Matters: A Randomized Phase 1 Study to Identify the Minimum Interval Necessary to Observe the H5 DNA Influenza Vaccine Priming Effect

Background. H5 DNA priming was previously shown to improve the antibody response to influenza A(H5N1) monovalent inactivated vaccine (MIV) among individuals for whom there was a 24-week interval between prime and boost receipt. This study defines the shortest prime-boost interval associated with an...

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Hlavní autoři: Ledgerwood, Julie E., Zephir, Kathryn, Hu, Zonghui, Wei, Chih-Jen, Chang, LeeJah, Enama, Mary E., Hendel, Cynthia S., Sitar, Sandra, Bailer, Robert T., Koup, Richard A., Mascola, John R., Nabel, Gary J., Graham, Barney S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699006/
https://ncbi.nlm.nih.gov/pubmed/23633407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit180
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